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Hi guys, I've been following the microbiome research for a few years now and just wanted to share my collection of diabetes (1 & 2) related info.


Review, Jan 2019: Impact of Gut Microbiota on Host Glycemic Control https://www.frontiersin.org/articles/10.3389/fendo.2019.00029/full
Review, 2018: The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into “Old” Diseases http://www.mdpi.com/2076-3271/6/2/32/htm
[Review, Dec 2017] Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases https://www.frontiersin.org/articles/10.3389/fimmu.2017.01882/full
[Review, Dec 2017] Microbial Regulation of Glucose Metabolism and Insulin Resistance: http://www.mdpi.com/2073-4425/9/1/10/htm
Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T-Cells (Feb 2019) "In mice with low incidence of autoimmune diabetes, broad-spectrum antibiotic treatment led to male mice developing accelerated diabetes" http://diabetes.diabetesjournals.org/content/early/2019/02/18/db18-0487
Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice (Nov 2018). Previous studies have shown that the gut microbiome is responsible for the benefits of fasting, & the benefits can be transferred via FMT. https://old.reddit.com/diabetes/comments/a1ugw2/intermittent_administration_of_a_fastingmimicking/easrqjo/
Some viruses produce insulin-like hormones that can stimulate human cells—and have potential to cause disease https://medicalxpress.com/news/2018-02-viruses-insulin-like-hormones-human-cellsand.html
Diabetes reversal after bypass surgery linked to changes in gut microorganisms https://www.sciencedaily.com/releases/2016/07/160711092303.htm
Gut bacteria imbalance increases diabetes risk http://www.eurekalert.org/pub_releases/2016-07/uoct-gbi071216.php
Analysis of a large cohort group has found a significant connection between gut microbes and 2 of the largest risk factors for diabetes: body mass index (BMI) and lipid levels: http://www.hcplive.com/medical-news/new-study-links-bmi-lipid-levels-to-gut-microbes
Immune system uses gut bacteria to control glucose metabolism: http://oregonstate.edu/ua/ncs/archives/2016/nov/immune-system-uses-gut-bacteria-control-glucose-metabolism
Metformin & Berberine Alter Gut Microbiota Composition in Diabetes http://www.sciencedirect.com/science/article/pii/S1550413117305715 - http://www.doctorslounge.com/index.php/news/pb/68025 - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042529 - http://agingfree.org/Portals/0/xBlog/uploads/2017/5/24/Metformin%20alters%20the%20gut%20microbiome%20of%20individuals.pdf
Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing (2018): https://www.sciencedirect.com/science/article/pii/S1568163718301855
Anti-diabetes drug, Acarbose, works via gut microbiome. Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue (2018): https://pubs.acs.org/doi/10.1021/acschembio.8b00309
The gut microbiota plays key role in diabetes treatment: https://www.drugtargetreview.com/news/23589/gut-microbiota-medication/ - https://newsroom.wakehealth.edu/News-Releases/2018/12/Gut-Microbiome-May-Affect-Some-Anti-Diabetes-Drugs
Researchers find bacterial protein that boosts insulin-producing cells in zebrafish: https://www.sciencedaily.com/releases/2016/12/161213130607.htm
Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents (2017): https://www.nature.com/articles/s41598-017-14010-x
Taking synbiotic supplements for 6 weeks among patients with gestational diabetes mellitus had beneficial effects on markers of insulin metabolism, TAG and VLDL-cholesterol concentrations. (2016) https://doi.org/10.1017/S0007114516003457
Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: A randomized controlled trial (2018): https://www.sciencedirect.com/science/article/abs/pii/S1871402118302832 "treatment decreased metabolic syndrome prevalence by 17% and 23% respectively"
Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes (2018, mice): https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(18)30394-2
Long term but not short term exposure to obesity related microbiota promotes host insulin resistance (2018): https://www.nature.com/articles/s41467-018-07146-5
Immune Response to Gut Microbes Linked to Diabetes Risk. "the findings suggest a mechanistic connection between immune recognition of microbes and autoimmunity genetics" (Feb 2019). https://www.the-scientist.com/news-opinion/immune-response-to-gut-microbes-linked-to-diabetes-risk-65416. Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children http://immunology.sciencemag.org/content/4/32/eaau8125

Type 1:

Review, 2018: Gut microbiome in type 1 diabetes: A comprehensive review https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3043
Review, 2018: Modulation of the immune system by the gut microbiota in the development of Type 1 Diabetes https://doi.org/10.1080/21645515.2018.1514354
Review, 2017: Microbiota: Diet can protect against type 1 diabetes: http://www.ncbi.nlm.nih.gov/pubmed/28422177
Single Course of Antibiotics Early in Life May Increase Type 1 Diabetes Risk (2018): https://www.genengnews.com/gen-news-highlights/single-course-of-antibiotics-early-in-life-may-increase-type-1-diabetes-risk/81256065 - https://doi.org/10.7554/eLife.37816
Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice (2018). https://msphere.asm.org/content/3/5/e00492-18 "results support a model for gut microbiota influence on T1D development involving bacterium-produced metabolites as butyrate"
Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice (Oct 2018). https://www.nature.com/articles/s41598-018-33571-z "Our results suggest that the algorithm could potentially be used in early prediction of future T1D development."
Study shows gut microbe composition different in young children with and without type 1 diabetes http://medicalxpress.com/news/2014-06-gut-microbe-composition-young-children.html
Yale study shows that gut microbes could trigger type 1 diabetes: http://www.diabetes.co.uk/news/2016/sep/yale-study-shows-that-gut-microbes-could-trigger-type-1-diabetes-99484927.html
Italian 2017 study ties inflammation, gut bacteria to type 1 diabetes: http://www.upi.com/Health_News/2017/01/19/Study-ties-inflammation-gut-bacteria-to-type-1-diabetes/3631484859891/
A study from the Aalto University finds that environmental factors such as the prevalence of antibiotics are part of what makes Finns the most likely in the world to contract Type I diabetes: http://yle.fi/uutiset/osasto/news/finnish_study_connects_infants_intestinal_microbes_to_childhood_diabetes/9530493
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice: http://www.nature.com/articles/nmicrobiol2016140
Multi-omic characteristics of the gut microbiome in individuals with T1DM compared to healthy relatives show a greater influence of microbes rather than genetics of T1DM. This study identifies the expression of T1DM-associated microbial functions to distinct taxa: http://www.gutmicrobiotaforhealth.com/en/integrated-multi-omics-study-human-gut-microbiome-four-families-multiple-cases-type-1-diabetes/
Gut bacteria can alter the protective effects of a gene that wards off type 1 diabetes: https://www.sciencedaily.com/releases/2017/08/170830155511.htm - Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny http://dx.doi.org/10.1073/pnas.1712280114
Type 1 diabetes risk linked to intestinal viruses. One virus may protect against disease, others may increase risk: https://medicine.wustl.edu/news/diabetes-risk-linked-to-intestinal-viruses/ - http://www.pnas.org/content/114/30/E6166.abstract
Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623193/

Type 2:

Review, 2018: Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System https://doi.org/10.3389/fnins.2018.00725
By destroying the mucous membrane in the small intestine and causing a new one to develop, scientists stabilized the blood sugar levels of people with type 2 diabetes. https://www.theguardian.com/society/2018/oct/24/spectacular-diabetes-treatment-could-end-daily-insulin-injections Duodenal Mucosal Resurfacing Elicits Improvement in Glycemic and Hepatic Parameters in Type 2 Diabetes—One-Year Multicenter Study Results (2018): http://diabetes.diabetesjournals.org/content/67/Supplement_1/1137-P
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1 (Oct 2018): https://doi.org/10.1016/j.cell.2018.09.055 "Our findings indicate that the microbial metabolite imidazole propionate may contribute to the pathogenesis of type 2 diabetes"
Metabolic improvement in obese patients after duodenal–jejunal exclusion is associated with intestinal microbiota composition changes (Feb 2019) https://www.nature.com/articles/s41366-019-0336-x "Improvement of obesity and type 2 diabetes after treatment may be promoted by changes in fecal microbiota composition"
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases (Feb 2019): https://www.nature.com/articles/s41588-019-0350-x "These data provide evidence of a causal effect of the gut microbiome on metabolic traits"
Fiber-fermenting bacteria improve health of type 2 diabetes patients (2018): https://www.sciencedaily.com/releases/2018/03/180308143047.htm
Further analysis reveals new gut microbiome markers of type 2 diabetes mellitus https://link.springer.com/article/10.1007/s10482-016-0805-3
A human gut phage catalog correlates the gut phageome with type 2 diabetes (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796561/
Researchers from the University of Eastern Finland found that an intestinal bacteria may protect against type 2 diabetes. Indolepropionic acid is a metabolite produced by intestinal bacteria, which comes from a high-fiber diet: http://www.upi.com/Health_News/2017/04/11/Study-shows-intestinal-bacteria-may-prevent-type-2-diabetes/9291491921870/
Type II diabetes may be reversible using caloric restriction: /AdvancedFitness/comments/4bjg5t/type_ii_diabetes_may_be_reversible_using_caloric/
Lactobacillus casei CCFM419 attenuated type 2 diabetes via gut microbiota dependent mechanism [mice]: http://pubs.rsc.org/en/content/articlelanding/2017/fo/c7fo00593h#!divAbstract - Full study via sci-hub.
Targeting gut microbiota: Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway [rats]: http://www.sciencedirect.com/science/article/pii/S1756464617305492 - Full study via sci-hub.
The association of type II diabetes with gut microbiota composition: http://www.sciencedirect.com/science/article/pii/S0882401017308045
Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes (2018): https://link.springer.com/article/10.1007%2Fs00125-018-4632-0 "Dietary intervention was found to modulate the gut microbiota and improve glucose control in individuals with type 2 diabetes."
Diabetes-Associated Alterations in the Cecal Microbiome and Metabolome are Independent of Diet or Environment in the UC Davis Type 2-Diabetes Mellitus Rat Model (2018): https://www.physiology.org/doi/abs/10.1152/ajpendo.00203.2018
I'll probably keep this post updated, and if you're interested in following this type of thing check out /HumanMicrobiome!


So what does this mean for people with diabetes? I think it suggests that you should be trying to target the gut microbiome. The main interventions are diet, probiotics, and FMT (Fecal Microbiota Transplants). There's lots of info on each of these in the /HumanMicrobiome sidebar & wiki!
submitted by MaximilianKohler to diabetes

Subreddit stats: Top posts from March 31 to April 7

Period: 6.97 days
Submissions Comments
Total 999 60742
Rate (per day) 143.29 8559.31
Unique Redditors 395 7554
Combined Score 118696 401447

Top Submitters' Top Submissions

  1. 9169 points, 48 submissions: mmmmmm-_-
    1. David Miliband: There’s nothing “left wing” about any kind of Brexit. It invites an unyielding job-cutting, standard-shredding, equality-reducing, regulation-shaving race to the bottom. No thanks. (1739 points, 414 comments)
    2. As the Sultan of Brunei introduces stoning for homosexuals, Richard Pendlebury asks… Why is a crack battalion of British Royal Gurkha Rifles still protecting this gold-plated bigot? (1135 points, 303 comments)
    3. EU slaps down Jacob Rees-Mogg for suggesting UK should deliberately cause chaos if Brexit is delayed (661 points, 287 comments)
    4. Pro-Europeans must unite around the opportunity of the EU elections - Brexit has created in the UK the biggest pro-EU movement in the bloc: let’s fight together (539 points, 109 comments)
    5. As it stands NO British food products or animals could be exported to the EU in the event of a No Deal Brexit, according to EU officials. It's because the UK still hasn't passed enough legislation for the EU to recognise it as a third country. (469 points, 183 comments)
    6. Just out of court on a case where the Home Office wants to remove a 78 year old woman with Advanced Alzheimer’s Dementia. They say she can be put in a care home in her own country for the time she has left. This is what Theresa May’s 2012 immigration rules mean. (454 points, 167 comments)
    7. Six in 10 Britons say Brexit uncertainty bad for mental health (404 points, 153 comments)
    8. Greens warn Labour will ‘never be forgiven’ if they usher in Brexit (299 points, 292 comments)
    9. Far-right activist Tommy Robinson banned from Snapchat (276 points, 405 comments)
    10. Third of Labour MPs pile pressure on Jeremy Corbyn to secure second referendum (273 points, 67 comments)
  2. 8797 points, 19 submissions: chowieuk
    1. A history of the BBC's abject failure to report on Vote Leave's cheating during the referendum campaign [Thread] (2316 points, 244 comments)
    2. Anna Turley MP - "Very amused by Rt Hon Lord Peter Lilley, Life Peer, member of the Privy Council, holder of 4 senior ministerial roles under Tory governments, Thatcher loyalist, former chair of the Bow Group, anti-climate change petroleum lobbyist, raging about the ‘establishment’ on my telly 😂" (1761 points, 231 comments)
    3. Projection on the white cliffs of dover (1237 points, 333 comments)
    4. Why is Britain turning blind eye to Leave side’s lawbreaking? Illegal fund activity linked to Brexit being ignored in belief ‘the people have spoken’ (819 points, 235 comments)
    5. 🇩🇪Germany’s Deputy Foreign Minister: 🥊“Brexit is a big shitshow, I say that now very undiplomatically” 🥊“90%” cabinet “no idea how workers think, live, work and behave” 🥊Politicians “born with silver spoons in their mouths, who went to private schools” that will not suffer (727 points, 169 comments)
    6. John Springford - "A reminder that a customs union is not soft Brexit. It only eliminates some tariff costs. The biggest costs of Brexit come from leaving the single market." (414 points, 192 comments)
    7. David Allen Green "In 2016 the "will of the people" via a referendum was for UK to leave EU. In 2017 the "will of the people" via a general election was for this to be done through a hung parliament. That parliament now failed. Difficult to argue against matter now being referred back to voters." (314 points, 169 comments)
    8. Michel Barnier recounts asking Nigel Farage about his vision for the future UK-EU relationship. Farage's response - "Mr Barnier. After Brexit the EU won't exist" (309 points, 193 comments)
    9. Rees-Mogg on Today programme this morning. Host asks him to clarify whether he supports any AFD policies. He then launches a tirade against the 'typical', 'lefty' BBC, refusing to answer the question. (210 points, 103 comments)
    10. Krishnan Guru-Murthy - "Sir Keir Starmer says : "So far, the Government isn't proposing any changes to the deal. In particular it's not countenancing any changes to the actual wording of the political declaration." WHAT HAVE THEY BEEN DOING??" (188 points, 52 comments)
  3. 7046 points, 24 submissions: LeftWingScot
    1. Nick Boles: I am no longer a member of the Conservative Party. So I can be blunt where previously I might have been discreet. The PM’s head of communications Robbie Gibb is a hard Brexiter who wants to destroy the PM’s new search for a cross party compromise. (2457 points, 371 comments)
    2. BREAKING Nick Boles resigns from the Conservative Party 'I accept I have failed. I have failed chiefly because my party has failed to compromise 'I regret that I have therefore resigned from this party' (1811 points, 534 comments)
    3. Blimey by ONE VOTE cooper Letwin Bill passes Commons stages - mandating PM to ask for extension. Backbenchers legislating against Government wishes... Ayes 313 Noes 312 (550 points, 434 comments)
    4. Boles says the PM has 'mismanaged and misunderstood' Brexit by only trying please the Tory party, never trying to construct a plan for the whole country, but party is gripped in combination of 'cowardice' from Remainers and 'dogma' from the Brexiteers that is 'not pretty' (387 points, 25 comments)
    5. 15 Tory MPs including government whip Mike Freer voted for a second referendum (258 points, 62 comments)
    6. Chris Heaton-Harris: After much contemplation, I have decided to leave Theresa May's Government. I'm grateful to the PM for giving me the opportunity to serve the UK and I will continue to represent my constituents as the MP for Daventry. (176 points, 117 comments)
    7. Quite incredible that after seven hours of a Cabinet discussion her only move forward is that she will talk to @jeremycorbyn In other words the Cabinet still cannot face up to the basic decisions - Corbyn has real power now. (176 points, 54 comments)
    8. Newport West result: LAB: 39.6% (-12.7) CON: 31.3% (-8.0) UKIP: 8.6% (+6.1) PC: 5.0% (+2.6) LDEM: 4.6% (+2.4) GRN: 3.9% (+2.8) RNW: 3.7% (+3.7) ATWA: 0.9% (+0.9) SDP: 0.9% (+0.9) D&V: 0.8% (+0.8) FBM: 0.7% (+0.7) Labour HOLD. (157 points, 202 comments)
    9. Extinction Rebellion: BREAKING: Extinction Rebellion activists strip off in House of Commons public gallery to call attention to the ‘elephant in the room’ — Climate and Ecological Crisis #ExtinctionRebellion #TellTheTruth (140 points, 37 comments)
    10. NEW: Channel 4 News can exclusively reveal a 16-fold rise in the use of Section 60 Stop and Search powers by the Metropolitan Police in just two years - while the number of stabbings has risen. (118 points, 19 comments)
  4. 5294 points, 18 submissions: zakkyb
    1. Private Eye on Daniel Hannan rewriting history (2189 points, 213 comments)
    2. In tonight’s Evening Standard, George Osborne responds to a letter from a Brexiter asking why Parliament does not have an answer to Brexit after 2 years (1143 points, 273 comments)
    3. Election Maps UK - How a General Election would look if 18-24's only were allowed to vote: Seats || Votes LAB: 541 || 55.0% SNP: 56 || 4.5% LDM: 25 || 14.0% SF: 10 || 0.9% PLC: 4 || 0.7% DUP: 4 || 0.4% CON: 3 || 14.5% IND: 2 GRN: 1 || 2.0% UUP: 1 || 0.4% ALL: 1 || 0.4% SDLP: 1 || 0.3% (369 points, 516 comments)
    4. Britain Elects - Britain leaving the European Union without any deal would be... A good outcome: 25% An acceptable compromise: 13% A bad outcome: 50% via @YouGov , 31 Mar - 01 Apr (287 points, 89 comments)
    5. The Adventures of Pinocchio (270 points, 7 comments)
    6. Matt on the European elections (261 points, 5 comments)
    7. Zambian resident how Brexit is being viewed by Sub-Saharan Africa (184 points, 24 comments)
    8. Nick Boles is a rare hero in a Parliament full of cowards (183 points, 43 comments)
    9. Election Maps UK - Would you support the British public having the final vote on Brexit, whatever the outcome of negotiations – whether a deal is reached or not? Support: 52% Oppose: 24% Don't Know: 24% Via @BMGResearch, 2-5 April. (138 points, 49 comments)
    10. Lisa Nandy MP - Take a look at where the Revoke Article 50 petition has got the fewest and most signatures. These are two Englands with differences in experience and outlook that run much deeper than the current divisions over Brexit (72 points, 64 comments)
  5. 3750 points, 23 submissions: OldTenner
    1. EU says it would not open talks with UK after no-deal Brexit until it agrees to divorce bill and Irish backstop (806 points, 625 comments)
    2. Rosie Cooper: "I was to be murdered to send a message to this place. Members of this House are regularly abused and attacked. Our freedoms, our way of life, our democracy is under threat" - MPs applaud as Labour's Rosie Cooper speaks out about neo-Nazi murder plot [video] (686 points, 383 comments)
    3. NEW - shadow foreign secretary Emily Thornberry writes to Labour MPs, insisting JC mustn't agree to any deal without a referendum attached. "Yes, any deal agreed by Parliament must be subject to a confirmatory public vote, and yes, the other option on the ballot must be Remain." (328 points, 54 comments)
    4. Alex Sobel: I’ve submitted this Parliamentary Question to @GavinWilliamson ‘To ask the Secretary of State for Defence what steps he has taken to investigate a video circulating on social media that depicts British soldiers using a picture of the Leader of the Opposition as target practice.’ (325 points, 184 comments)
    5. BREAKING: Labour confirms it WILL be backing Common Market 2.0. (294 points, 385 comments)
    6. Nigel Adams: Following yesterday’s cabinet, this morning I’ve been to Downing Street & resigned my position as UK Govt Minister for Wales & Govt Whip. I’m grateful to the PM for the opportunity to serve as a Minister since 2017 & will continue to serve my constituents from the backbenches. (274 points, 98 comments)
    7. Laura Kuenssberg: Just been sent this - said to be circulating now in Commons- motion that would censure the Prime Minister and some ministers and even dock their pay - not sure if this will pick up much support, but shows some Tories are very very angry this morning (151 points, 42 comments)
    8. Laura Kuenssberg: Whispers this morning that clerks in Commons have made it clear to govt that Bercow would not allow them to bring back the deal for another vote - one source says this is a 'BIG PROBLEM' - with capital letters - BUT Speaker's office says not decided yet - let's see (135 points, 73 comments)
    9. Philip Hammond refuses to rule out second Brexit referendum | the Chancellor said the government had "no red lines" during its Brexit discussions with Labour (105 points, 38 comments)
    10. The Govt are defeated in their attempt to block #IndicativeVotes2 today. 322/277 a majority of 45. The debate will last until 8pm with votes between 8-830pm on 📝 (102 points, 31 comments)
  6. 2996 points, 27 submissions: BothBawlz
    1. April Fool's jokes banned amid fear of panic buying over Brexit (845 points, 74 comments)
    2. Guillaume Chaslot (@gchaslot) Tweeted: The Philippines is the country in the world with the highest use of social media per day. From 2015 to 2018, the belief that vaccines are important decreased there from 93% to 32%. This country is a canary in the coal mine. (414 points, 58 comments)
    3. Pippa Crerar Tweeted: All eyes on PMQs later. Worth remembering that just SEVEN days ago Theresa May declared: "The biggest threat to our standing in the world, to our defence and to our economy is sitting on the Labour front bench.” Suspect she won't be repeating that today (h/t @JBeattieMirror) (323 points, 40 comments)
    4. Tim Farron (@timfarron) Tweeted: @NickBoles tells me that he’s voted for a people’s vote in the indicative votes. So have I (of course), and in the spirit of compromise and finding common ground, I have also voted for Common Market 2.0 (209 points, 30 comments)
    5. House of Lords -- Business of the House; European Union (Withdrawal) (No. 5) Bill AKA Cooper-Letwin Extension Bill; beginning at approximately Thursday 4 April 2019 at 11.30am BST (177 points, 1259 comments)
    6. The options for tomorrow's (Monday, 2019-04-01) indicative votes: (169 points, 392 comments)
    7. Claire Perry Tweeted: @Telegraph I don’t ever comment on Cabinet meetings but must do now because your headline is based on totally inaccurate leaks from a colleague behaving reprehensibly. There were only FOUR cabinet members who spoke explicitly today in favour of no extension and no deal. (120 points, 29 comments)
    8. May: My deal? Commons: No. May: My deal? Commons: No. May: 30th of June? European Council: No. May: My deal? Commons: No. May: 30th of June? European Council: (TBD -- No). (120 points, 38 comments)
    9. Today Liberal Democrat Brexit Spokesperson, Tom Brake MP, will present a bill which would require the Prime Minister to resign should the House of Commons pass a motion of no confidence in her. (112 points, 58 comments)
    10. Sam Coates Times (@SamCoatesTimes) Tweeted: Theresa May has been “very clear” the Tory party will not let Dominic Grieve be deselected despite Friday’s no confidence vote claims Victoria Atkins (98 points, 36 comments)
  7. 2811 points, 11 submissions: bottish
    1. Der Englische Patient (1798 points, 111 comments)
    2. Guy Verhofstadt on Twitter: We cannot risk giving the keys of the EU’s future to a Boris Johnson, or a Michael Gove, the architects of this #Brexit disaster. A long extension would do exactly that. (281 points, 86 comments)
    3. Brexit is turning Britain into a laughing stock, says Siemens UK boss (247 points, 108 comments)
    4. Nicola Sturgeon tells EU citizens in Scotland: ‘You are welcome here’. Support package launched amid concerns many in rural areas do not know they must apply for settled status. (152 points, 111 comments)
    5. No.10 statement: Look out for Theresa May's no-deal trap. It all sounded so reasonable and open. And that was probably the first indication that something could be wrong. Theresa May's statement in Downing Street today, just like all her Brexit commentary, was extremely murky and unclear. (112 points, 18 comments)
    6. Tory members back no-deal Brexit and Johnson as Prime Minister. Three quarters of Tory members want to leave the EU without a deal, a new survey has revealed, in a further indication a hardline Brexiteer such as Boris Johnson is their preferred successor to Theresa May. (86 points, 62 comments)
    7. Opinion: Amid the chaos of Brexit, Scotland is a beacon of sense in a sea of madness. (56 points, 15 comments)
    8. "Until no deal is off the table - and May should have taken it off the table a long time ago - we can't be certain that certain medicines might not run out" - Dr Kirsty Hughes. (33 points, 26 comments)
    9. German economy will grow 0.7 percent this year if Brexit is disorderly: BDI (19 points, 1 comment)
    10. Two devices left on rail lines in suspected pro-Brexit sabotage plot. Police investigate ‘malicious obstructions’ that were meant to disrupt train services (16 points, 9 comments)
  8. 2679 points, 21 submissions: jaydenkieran
    1. Ian Blackford: "In all eventualities, there must be a people's vote" SNP, Lib Dems, Plaid Cymru, Greens and the Independent Group issue joint statement saying they will push for a public vote to be included in #Brexit legislation (512 points, 204 comments)
    2. BREAKING: BBC News understands HMP Birmingham is being permanently brought back into public ownership. The jail has been operated by G4S since 2011 and had 7 more years of the contract to run. Prison Service has been managing the jail since last August after a damning inspection. (405 points, 110 comments)
    3. JRM: If a long extension leaves us stuck in the EU we should be as difficult as possible. We could veto any increase in the budget, obstruct the putative EU army and block Mr Macron’s integrationist schemes. (307 points, 321 comments)
    4. “You are sounding like a member of the ERG, it’s your duty to be probing” Ken Clarke to Andrew Neil during Politics Live (302 points, 139 comments)
    5. Krishnan Guru-Murthy: A male MP we asked to come on for this discussion about the abusive language and behaviour around Brexit told our producer to get stuffed and shove the programme up his ****. There have always been a few thickies in parliament but they were generally polite. No more. (276 points, 117 comments)
    6. Peston: So @CiceroGlobal have crunched the numbers and have @NickBoles's Common Market 2.0 motion winning by 307 to 253, now that Labour are whipping in favour of it. As the least Brexity of all the Brexit options, that would put an enormous predatory cat among the Tory pigeons... (180 points, 173 comments)
    7. Prime Minister Theresa May says the UK needs an extension to Article 50 which is "as short as possible" in order to leave the EU with a deal (109 points, 148 comments)
    8. Chris Leslie MP: "Seven hours for that?! Two main political parties to carve up a deal agreeing #Brexit and then fudge some words in the non-binding ‘political declaration’? No thanks! At @TheIndGroup we believe British public must have chance to think again and stay in EU with #PeoplesVote" (90 points, 64 comments)
    9. NEW - Downing Street sources confirm whipping for tonight - Tory MPs will be instructed to vote against the business motion, setting up indicative votes; given free votes on the Brexit options; but cabinet ministers will (again) be ordered to abstain. (90 points, 32 comments)
    10. NEW: PM’s spokesman bats away Chancellor’s claim on #peston that second referendum is a “perfectly credible proposition”. No 10 says it has been rejected in Parliament 3 times. But not totally ruling out a People’s Vote being discussed during talks with Corbyn. (64 points, 30 comments)
  9. 2087 points, 4 submissions: JohnJohnKennedy
    1. The United Kingdom Has Gone Mad - The problem with holding out for a perfect Brexit plan is that you can’t fix stupid. (1436 points, 620 comments)
    2. Funny business at work in the voting lobbies? A minister was counted by Tory whips and then nipped back in to try and be counted twice. Eagle-eyed Labour whip Nick Smith spotted him and he was caught out, source tells me. (411 points, 132 comments)
    3. No Deal Brexit: "It's as serious as it gets". Please watch this clip in which a Consultant doctor risks his career by ignoring a legal gag to bring you the truth about No Deal. (230 points, 49 comments)
    4. Ford Europe’s Steven Armstrong warns jobs could be at risk in the event of a no deal Brexit. (10 points, 7 comments)
  10. 1966 points, 18 submissions: Pro4TLZZ
    1. Barnier today stressing that no deal isn't the end of the process. If/when the UK comes back to table after several months of turmoil, £39bn citizens rights and Irish backstop will be price of admission. Back to where we started, in an even weaker negotiating position. (588 points, 447 comments)
    2. The House of Commons printer has broken down so they can't print the Cooper Bill. So now MPs are not sure what they are now debating. (530 points, 157 comments)
    3. Tories Graham Brady overturns Grieve confidence vote saying no Conservative MP will be subject to de selection and grass root members cannot have a say in this as it is down to parliamentary party to decide issues like this .So Grieve STAYS (166 points, 106 comments)
    4. . @normanlamb who was behind two of tonight‘s motions is furious. Tells me “i am ashamed to be a member of this parliament “ and accuses colleagues including fellow libdems of “posturing and not being prepared to compromise “ (134 points, 92 comments)
    5. Full DUP reaction to the PM’s offer. (89 points, 51 comments)
    6. Lib Dems will NOT back Common Market 2.0, I’m told. Their problem is because @NickBoles said it could go ahead with a May 22 Brexit date, which gives no time for a People’s Vote (84 points, 114 comments)
    7. Leave Alliance: Brexiteers didn't want a plan and they cry betrayal. They voted down an exit deal three times and now they complain at an extension. They're going to wail about anything that isn't a completely non-existent perfection which is unobtainable since they keep shifting the goalposts. (81 points, 24 comments)
    8. Real anger. among Common Market 2.0 Lab MPs that 33 Peoples Vote colleagues abstained on the Boles motion. (78 points, 54 comments)
    9. I’ve had MPs of all sides saying they’re “holding out” in the hope their preferred option will emerge as the last minute fallback. The UK leaves the EU in 11 days unless an extension is requested or another option is agreed. (46 points, 12 comments)
    10. Children in low-income families suffer 'shame and social exclusion' | Society (28 points, 6 comments)

Top Commenters

  1. ITried2 (4462 points, 411 comments)
  2. potpan0 (3297 points, 197 comments)
  3. JohnJohnKennedy (2242 points, 247 comments)
  4. Jim-Plank (2032 points, 57 comments)
  5. Maximus-city (1984 points, 113 comments)
  6. BothBawlz (1833 points, 539 comments)
  7. pickled-egg (1737 points, 179 comments)
  8. thatawkwarddanguy (1681 points, 49 comments)
  9. feshfegner (1678 points, 182 comments)
  10. Pauln512 (1673 points, 116 comments)

Top Submissions

  1. Nick Boles: I am no longer a member of the Conservative Party. So I can be blunt where previously I might have been discreet. The PM’s head of communications Robbie Gibb is a hard Brexiter who wants to destroy the PM’s new search for a cross party compromise. by LeftWingScot (2457 points, 371 comments)
  2. A history of the BBC's abject failure to report on Vote Leave's cheating during the referendum campaign [Thread] by chowieuk (2316 points, 244 comments)
  3. Private Eye on Daniel Hannan rewriting history by zakkyb (2189 points, 213 comments)
  4. [Math (er, maths)] Graph theory indicates that there does exist a consensus winner among all 13 options voted on in Parliament: Kyle's Motion E for a Confirmatory Public Vote. by Kwarizmi (1822 points, 332 comments)
  5. BREAKING Nick Boles resigns from the Conservative Party 'I accept I have failed. I have failed chiefly because my party has failed to compromise 'I regret that I have therefore resigned from this party' by LeftWingScot (1811 points, 534 comments)
  6. Der Englische Patient by bottish (1798 points, 111 comments)
  7. Anna Turley MP - "Very amused by Rt Hon Lord Peter Lilley, Life Peer, member of the Privy Council, holder of 4 senior ministerial roles under Tory governments, Thatcher loyalist, former chair of the Bow Group, anti-climate change petroleum lobbyist, raging about the ‘establishment’ on my telly 😂" by chowieuk (1761 points, 231 comments)
  8. David Miliband: There’s nothing “left wing” about any kind of Brexit. It invites an unyielding job-cutting, standard-shredding, equality-reducing, regulation-shaving race to the bottom. No thanks. by mmmmmm-_- (1739 points, 414 comments)
  9. Petition to change the voting system to one of proportional representation by smithy51 (1579 points, 619 comments)
  10. So... this week's Sky data poll showed the public backed a second referendum by 40% vs 35% against. They also reject no deal by 9% and May's deal by 16%. So how did the BBC choose to present the data on Marr today with one single graphic... ? (image attached) by Pauln512 (1578 points, 263 comments)

Top Comments

  1. 828 points: ldn6's comment in Nick Boles: I am no longer a member of the Conservative Party. So I can be blunt where previously I might have been discreet. The PM’s head of communications Robbie Gibb is a hard Brexiter who wants to destroy the PM’s new search for a cross party compromise.
  2. 743 points: prettybunbun's comment in BREAKING Nick Boles resigns from the Conservative Party 'I accept I have failed. I have failed chiefly because my party has failed to compromise 'I regret that I have therefore resigned from this party'
  3. 665 points: RosemaryFocaccia's comment in Petition to change the voting system to one of proportional representation
  4. 650 points: potpan0's comment in This is @theresa_may and Cabinet trying to shift to Labour responsibility for a no-deal Brexit on 12 April. PM says it is no deal unless Labour negotiates responsibly
  5. 608 points: wanado144's comment in BREAKING Nick Boles resigns from the Conservative Party 'I accept I have failed. I have failed chiefly because my party has failed to compromise 'I regret that I have therefore resigned from this party'
  6. 591 points: LastCatStanding_'s comment in May asks EU for Brexit extension until 30 June
  7. 510 points: fanglord's comment in This is @theresa_may and Cabinet trying to shift to Labour responsibility for a no-deal Brexit on 12 April. PM says it is no deal unless Labour negotiates responsibly
  8. 497 points: bobbykjack's comment in [Math (er, maths)] Graph theory indicates that there does exist a consensus winner among all 13 options voted on in Parliament: Kyle's Motion E for a Confirmatory Public Vote.
  9. 454 points: Nouse4livE's comment in EU says it would not open talks with UK after no-deal Brexit until it agrees to divorce bill and Irish backstop
  10. 454 points: ShufflingToGlory's comment in Just talked to two ERG MPs. Angry doesn’t quite cut it. “This is serious stuff. She has fucked our party. She is fucking brexit. She is fucking the country.”
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